evaluation of iron deposition in the adrenal glands of β thalassemia major patients using 3-tesla mri
نویسندگان
چکیده
conclusion adrenal iron in β-tm can be reliably measured in 3 tesla mri. the results highlight the absence of correlation between adrenal iron deposition both with serum ferritin and hepatic iron. results among patients, there was no significant correlation between plasma ferritin and adrenal t2*. significant difference was detected among t2* values of adrenals between the patient and control groups. there was no significant correlation between adrenal gland and liver t2* in β-tm patients, moderate correlation was detected between adrenal t2* and cardiac t2*. patients and methods between october 2014 and march 2015, mri was performed in 21 patients with β-tm, recieving blood transfusions and chelation therapy. the control group (n = 11) included healthy volunteers with no known history of adrenal, hematologic, chronic disease, and blood transfusion. objectives the aim was to measure adrenal iron load with t2* relaxometry using mri, and to compare it with liver and cardiac iron and serum ferritin, and to find out whether adrenal iron could be predicted from those parameters. background beta-thalassemia major (β-tm) patients need blood transfusions, which result in iron deposition. to regulate chelation therapy, iron load has to be measured. with mri, the amount of signal loss and t2* decay time shortening are used for iron quantification.
منابع مشابه
Evaluation of Iron Deposition in the Adrenal Glands of β Thalassemia Major Patients Using 3-Tesla MRI
BACKGROUND Beta-thalassemia major (β-TM) patients need blood transfusions, which result in iron deposition. To regulate chelation therapy, iron load has to be measured. With MRI, the amount of signal loss and T2* decay time shortening are used for iron quantification. OBJECTIVES The aim was to measure adrenal iron load with T2* relaxometry using MRI, and to compare it with liver and cardiac i...
متن کاملEVALUATION OF PULMONARY IRON OVER LOAD IN PATIENTS WITH Β-THALASSEMIA MAJOR USING SPIROMETRY
Background & Aims: Spirometry changes in thalassemic patients can be obstructive or restrictive and pulmonary dysfunction depends on age and body iron overload. In this study the effectiveness of lung spirometry in detecting iron overload in patients with β-thalassemia was investigated. Materials & Methods: This cross-sectional (descriptive-analytic) study investigated the spirometry test resu...
متن کاملMRI Evaluation of Liver Iron Concentration in Patients with β-Thalassemia Major
β major is a hereditary anemia, characterized by a genetic deficiency in the synthesis of the β-globin chain (1). The main complication of the multiple blood transfusions to these patients is iron overload and the deposition of iron in various organs, such as the reticuloendothelial system, the liver, the heart and the endocrine glands (2). Chelators also have various side effects on multiple o...
متن کاملCorrelation between Heart and Liver Iron Levels Measured by MRI T2* and Serum Ferritin in Patients with β-thalassemia Major
Background Transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. This study aimed to compare the level of iron stored in the liver and heart measured by MRI T2 * with ferritin levels in these patients. Materials and Methods This study was done on 52 patients with β-thalassemia major aged 7 to 29 years. Serum ferritin level was checked and heart and ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of radiologyجلد ۱۳، شماره ۳، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023